Fred has converted his garage into a laboratory, in which he is combining chemicals in an attempt to concoct a wealth-and-fame-earning, new soft drink. Meanwhile, Barney, plagued with persistent hic-coughing, is urged by Betty to visit a Dr. Quartz in search for a hic-cough cure. When Fred learns of Barney's affliction, he insists that Barney forgo a costly visit to a doctor (Stone Age physicians are quacks anyway) and permit him to endeavor a cure. Conventional methods, involving a paper bag over the head and sudden fright with a thrown hatchet, prove ineffective.
So, Fred supplies his latest chemical mixture for Barney to drink- and it halts the hiccoughs and turns Barney invisible. Fred is unable to reverse the vanishing process, and he escorts Barney to Dr. Quartz in the hope that Quartz can supply an antidote. First though, Fred and Barney stop at the Bedrock Bowling Alley, where Fred uses Barney's unseen presence to foil a braggart named Blowhard Sandstone, who challenges Fred to a bowling string. Barney tampers with Blowhard's bowling balls, causing them to go into gutters or stop before striking pins and reverse course back to a confounded Blowhard, and Fred's wild delivery is aided by Barney to garner strikes every time- even when Fred is blindfolded and releases the bowling ball from between his legs!
Blowhard bursts into tears when he loses to Fred. Fred and Barney resume their travel in Barney's car (with invisible Barney driving the vehicle and startling a policeman on duty at an intersection) and arrive at the office of Dr. Quartz. Quartz is unable to restore Barney to visibility, but Fred's formula eventually "wears off", and Barney can be seen again. Still, all is not normal, for Dino has sampled some of Fred's drought and jumps unseen on top of Fred.
- Fred Flintstone
- Wilma Flintstone
- Barney Rubble
- Betty Rubble
- Blowhard Sandstone (only appearance)
- Dr. Quartz (only appearance)
- Hair Grower (only mentioned)
- 411up (only appearance)
- 412up (only appearance)
- Paper bag (only appearance)
- Mammoth (as a laundry sink)
- Dodo Bird (as Dodo eggs, mentioned)
- Brontosaurus (as Corned Brontosaurus)
- Pterodactyl (as Onion Pterodactyl Sandwiches, mentioned)
- Saber-Toothed Tiger (mentioned)
|Alan Reed||Fred Flintstone|
|Jean Vander Pyl||Wilma Flintstone|
|Mel Blanc|| Barney Rubble|
|Bea Benaderet|| Betty Rubble|
|John Stephenson|| Blowhard Sandstone|
|Hal Smith|| Announcer|
|Howard McNear||Dr. Quartz|
- Blowhard's last name is Sandstone. The elephant is named Cicero, an unlikely name for a Flintstones character.
- This episode is sometimes known as "Invisible Barney".
- This is the first episode where the now-famous "Meet the Flintstones" song is used and becomes the show's main theme which replaced "Rise and Shine", the instrumental song from the first and second seasons plus the previous two episodes of the third season.
- It is also the first episode for the DVD to use the new credits and theme as well.
- During the bowling match, Blowhard is shown shooting an 8 on one of his frames, missing the 7-10 split, but later according to the score sheet, it shows that he has not scored above 4 in any of his frames.
- After Blowhard misses all the pins with his first two throws he moves over to the next lane for another turn even though none of the other lanes have pins set up on them and it isn't his turn anyway.
- When Wilma is talking to Betty while she is dusting she picks up the vase and dusts under it twice.
|Season 3 of The Flintstones|
|"Dino Goes Hollyrock" • "Fred's New Boss" • "Barney the Invisible" • "Bowling Ballet" • "The Twitch" • "Here's Snow in Your Eyes" • "The Buffalo Convention" • "The Little Stranger" • "Baby Barney" • "Hawaiian Escapade" • "Ladies' Day" • "Nuthin' But the Tooth" • "High School Fred" • "Dial 'S' for Suspicion" • "Flash Gun Freddie" • "The Kissing Burglar" • "Wilma the Maid" • "The Hero" • "The Surprise" • "Mother-in-Law's Visit" • "Foxy Grandma" • "Fred's New Job" • "The Dress Rehearsal" • "Carry On, Nurse Fred" • "Ventriloquist Barney" • "The Big Move" • "Swedish Visitors" • "The Birthday Party"|